Backx P
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Basic Res Cardiol. 1993;88 Suppl 2:21-8.
The efficiency of cardiac muscle can be easily defined using thermodynamics and statistical mechanics. While thermodynamic definitions allow absolute measures of efficiency in terms of work output and free energy input, they do not provide insights into the underlying contraction mechanisms. The construction of molecular kinetics models of muscle, such as the cross-bridge theory, in conjunction with the use of statistical mechanics provides a framework for the examination of efficiency. The expressions of efficiency derived in this manner will be thermodynamically consistent and can be compared to experimental measurements, thereby rendering insight into cardiac energetics.
利用热力学和统计力学可以轻松定义心肌的效率。虽然热力学定义允许根据功输出和自由能输入来绝对衡量效率，但它们并未深入揭示潜在的收缩机制。肌肉分子动力学模型的构建，如横桥理论，结合统计力学的使用，为研究效率提供了一个框架。以这种方式得出的效率表达式在热力学上是一致的，并且可以与实验测量结果进行比较，从而深入了解心脏能量学。
