唾液酸和唾液酸糖缀合物对牛脑胞质磷脂酶A2的影响。
Effects of sialic acid and sialoglycoconjugates on cytosolic phospholipases A2 from bovine brain.
作者信息
Yang H C, Farooqui A A, Horrocks L A
机构信息
Department of Medical Biochemistry, Ohio State University, Columbus 43210.
出版信息
Biochem Biophys Res Commun. 1994 Mar 30;199(3):1158-66. doi: 10.1006/bbrc.1994.1352.
Two forms of Ca(2+)-independent cytosolic phospholipases A2 were separated by Sephadex G-75 column chromatography. N-Acetylneuraminic acid, gangliosides, and sialoglycoproteins inhibited both phospholipases A2 in a concentration dependent manner, but colominic acid, poly(2,8-N-acetylneuraminic acid), had no effect on enzymic activities. Interactions between phospholipases A2 and sialoglycoconjugates may be involved in the translocation of phospholipases A2 from cytosol to plasma membrane during receptor stimulation.
通过葡聚糖G-75柱层析分离出两种不依赖钙离子的胞质磷脂酶A2。N-乙酰神经氨酸、神经节苷脂和唾液酸糖蛋白以浓度依赖的方式抑制这两种磷脂酶A2，但N-乙酰神经氨酸聚合物（colominic acid）对酶活性没有影响。磷脂酶A2与唾液酸糖缀合物之间的相互作用可能参与受体刺激过程中磷脂酶A2从胞质溶胶向质膜的转运。
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