Yang H C, Farooqui A A, Horrocks L A
Department of Medical Biochemistry, Ohio State University, Columbus 43210, USA.
J Lipid Mediat Cell Signal. 1996 Sep;14(1-3):9-13. doi: 10.1016/0929-7855(96)01502-7.
The breakdown of plasmalogens in neural membranes is a receptor-mediated process catalyzed by a plasmalogen-selective phospholipase A2. This enzyme has been isolated from bovine brain. It is localized in cytosol and does not require Ca2+ for its activity. It has a molecular weight of 39 kDa and is strongly inhibited by glycosaminoglycans, gangliosides and sialoglycoproteins. The interactions between plasmalogen-selective phospholipase A2 and glycoconjugates may be involved in the regulation of enzymic activity. Under normal conditions, plasmalogen-selective phospholipase A2 provides second messengers such as arachidonic acid and eicosanoids. However, under pathological conditions, this enzyme may be involved in a massive release of free fatty acids that may cause serious cell and tissue damage.
神经膜中缩醛磷脂的分解是一个由缩醛磷脂选择性磷脂酶A2催化的受体介导过程。这种酶已从牛脑中分离出来。它定位于胞质溶胶中，其活性不需要Ca2+。它的分子量为39 kDa，受到糖胺聚糖、神经节苷脂和唾液酸糖蛋白的强烈抑制。缩醛磷脂选择性磷脂酶A2与糖缀合物之间的相互作用可能参与酶活性的调节。在正常情况下，缩醛磷脂选择性磷脂酶A2提供第二信使，如花生四烯酸和类花生酸。然而，在病理条件下，这种酶可能参与游离脂肪酸的大量释放，这可能导致严重的细胞和组织损伤。
