4,5',8-三甲基补骨脂素对红细胞膜的光物理改变：膜对补骨脂素光疗的反应
Photophysical alterations of erythrocyte membrane by 4,5',8-trimethyl psoralen: membrane response towards psoralen phototherapy.
作者信息
Nivsarkar M, Kumar G P, Laloraya M
机构信息
SIR Hurrkisondas Nurrotumdas Medical Research Society, Bombay, India.
出版信息
Biochem Biophys Res Commun. 1994 Mar 30;199(3):1413-21. doi: 10.1006/bbrc.1994.1388.
Despite the wide and versatile use of psoralen phototherapy in various dermal diseases including psoriasis and leukoderma, the proposed mechanism of action of psoralen is disputed. This study launches an original documentation of free-radical resulting in erythrocyte membrane damage studied by spin-labeling using the probes malnet and 5 doxyl stearate as protein and lipid domains, respectively. Both Type I and Type II photodynamics appear plausible and the therapeutic aspects of this innovation are being verified.
尽管补骨脂素光疗在包括牛皮癣和白斑病在内的各种皮肤病中得到广泛且多样的应用，但补骨脂素的作用机制仍存在争议。本研究通过自旋标记分别使用探针马尔尼特和5-硬脂酰氧基硬脂酸作为蛋白质和脂质结构域，对导致红细胞膜损伤的自由基进行了原始记录。I型和II型光动力学似乎都有道理，这一创新的治疗方面正在得到验证。
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