低剂量环孢素A对系统性红斑狼疮疾病活动的影响。

Effect of low-dose cyclosporin A on systemic lupus erythematosus disease activity.

作者信息

Tokuda M, Kurata N, Mizoguchi A, Inoh M, Seto K, Kinashi M, Takahara J

机构信息

First Department of Internal Medicine, Kagawa Medical School, Japan.

出版信息

Arthritis Rheum. 1994 Apr;37(4):551-8. doi: 10.1002/art.1780370416.

DOI:10.1002/art.1780370416

PMID:8147933

Abstract

OBJECTIVE

To determine the effect of low-dose cyclosporin A (CSA) treatment on disease activity in systemic lupus erythematosus (SLE).

METHODS

All patients in the study had active disease as defined by at least the presence of a low CH50 level. Patients were initially given 3 mg/kg/day of CSA. Dosages were adjusted individually at every visit, according to both clinical and laboratory data.

RESULTS

Eleven women with SLE were enrolled in the study; 10 were evaluable. After 20 weeks of CSA treatment, the mean score for disease activity on the SLE Disease Activity Index decreased significantly, from 10.6 to 3.8 (P = 0.02). The titer of antinuclear antibodies decreased in 8 patients and the level of anti-DNA antibodies decreased in 5. Side effects included hypertension (40%), hypertrichosis (30%), gingival hypertrophy (10%), and a rise in the blood urea nitrogen level. Serum creatinine levels remained unchanged.

CONCLUSION

The favorable responses observed in our patients strongly suggest that low-dose CSA can reduce the disease activity of SLE.

摘要

目的

确定低剂量环孢素A（CSA）治疗对系统性红斑狼疮（SLE）疾病活动的影响。

方法

本研究中的所有患者均有活动性疾病，定义为至少存在低CH50水平。患者最初给予3mg/kg/天的CSA。每次就诊时根据临床和实验室数据对剂量进行个体化调整。

结果

11名SLE女性患者纳入研究；10名可评估。CSA治疗20周后，SLE疾病活动指数的疾病活动平均评分显著降低，从10.6降至3.8（P = 0.02）。8例患者抗核抗体滴度降低，5例患者抗DNA抗体水平降低。副作用包括高血压（40%）、多毛症（30%）、牙龈增生（10%）以及血尿素氮水平升高。血清肌酐水平保持不变。