左羟丙哌嗪对犬的镇咳作用
Antitussive effects of levodropropizine in the dog.
作者信息
Munt P L, Clavenna G, Algate D R, Leach R M
机构信息
Department of Pharmacology, Huntingdon Research Centre, UK.
出版信息
Arzneimittelforschung. 1994 Feb;44(2):153-5.
PMID:8147948
Abstract
The antitussive activity of levodropropizine (S(-)3-(4-phenyl-piperazine-1-yl)-propane-1,2-diol, DF 526, CAS 99291-25-5) was evaluated after oral administration to the conscious dog. Levodropropizine had a good antitussive activity, comparable with, but having a longer duration of action than dropropizine, the racemate from which it is derived. The antitussive activity of levodropropizine in the dog was approximately 1/20 of that of codeine phosphate.
摘要
在对清醒犬口服给药后，评估了左羟丙哌嗪（S(-)-3-(4-苯基-哌嗪-1-基)-丙烷-1,2-二醇，DF 526，CAS 99291-25-5）的镇咳活性。左羟丙哌嗪具有良好的镇咳活性，与它所衍生的消旋体右羟丙哌嗪相当，但作用持续时间更长。左羟丙哌嗪在犬体内的镇咳活性约为磷酸可待因的1/20。
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