Liu X S, Luo Z H, Yang Z C, Huang W H, Li A N
Institute of Burn Research, Southwestern Hospital, Third Military Medical College, Chongqing, Sichuan, PR China.
Burns. 1994 Feb;20(1):40-4. doi: 10.1016/0305-4179(94)90104-x.
In order to explore the pathogenesis of postburn internal organ injury (OI) and multiple organ failure (MOF), serum TNF activity was measured by biological assay in 24 severely burned patients. Parameters related to internal organ functions were simultaneously measured. The results showed an obvious increase in serum TNF activity accompanied by increased serum myocardial and hepatic enzymes, plasma lactate and aggregations of WBC in internal organ tissues. Serum protein levels decreased substantially. These changes were more marked in patients suffering from both OI and MOF. It is suggested that large amounts of TNF are produced postburn and might have an important role in the development of OI and MOF.
为了探讨烧伤后内脏损伤（OI）和多器官功能衰竭（MOF）的发病机制，采用生物学检测法对24例重度烧伤患者的血清TNF活性进行了检测。同时测定了与内脏功能相关的参数。结果显示，血清TNF活性明显升高，同时伴有血清心肌酶和肝酶升高、血浆乳酸升高以及内脏组织中白细胞聚集。血清蛋白水平显著下降。这些变化在同时患有OI和MOF的患者中更为明显。提示烧伤后产生大量TNF，可能在OI和MOF的发生发展中起重要作用。
