Bo P, Soragna D, Murelli R, Albergati A, Savoldi F
Istituto Neurologico C. Mondino Università di Pavia.
Boll Soc Ital Biol Sper. 1993 Jun;69(6):387-93.
It has been shown that neuroleptics which interact selectively with either D-1 or D-2 dopamine receptors possess a marked difference in their propensity on seizures. The aim of this work was to investigate whether the D-1 antagonist SCH 23390 differs from haloperidol (D-2 antagonist) in models of experimental epilepsy induced by electrical stimulation of selected brain regions (hippocampus and amygdala), in rabbits. Haloperidol increased and SCH 23390 significantly decreased the susceptibility to seizures in both models investigated. The data suggest that the D-1 and D-2 receptor subtypes have different roles in the mechanisms underlying seizures.
已经表明，选择性地与D-1或D-2多巴胺受体相互作用的抗精神病药物在引发癫痫的倾向方面存在显著差异。这项工作的目的是研究在兔中，通过电刺激选定脑区（海马体和杏仁核）诱导的实验性癫痫模型中，D-1拮抗剂SCH 23390是否与氟哌啶醇（D-2拮抗剂）不同。在研究的两种模型中，氟哌啶醇增加了癫痫易感性，而SCH 23390显著降低了癫痫易感性。数据表明，D-1和D-2受体亚型在癫痫发作的潜在机制中具有不同作用。
