Bo P, Savoldi F
Institute of Neurology C. Mondino, University of Pavia, School of Medicine, Italy.
Pharmacol Res. 1992 Jul-Aug;26(1):67-74. doi: 10.1016/1043-6618(92)90706-h.
The neuroleptics SCH 23390 and raclopride, which interact selectively with either D-1 or D-2 dopamine receptor, were studied for their effects on electroencephalographic (EEG) activity in the rabbit. Haloperidol (0.3 and 1 mg/kg intravenously, i.v.), which was used for comparison, induced synchronization of the cortical EEG activity. Spectral EEG analysis showed increase of power in the whole frequency range (0.1-38.5 Hz) and in all frequency bands in the cortex, whereas a slight decrease of slow and fast theta activity (3.7-7.2 and 7.2-12.2 Hz) was observed in the hippocampus. Animals appeared sedated and arousal response to somatosensory stimuli was markedly inhibited. SCH 23390 (0.03 and 0.3 mg/kg i.v.) induced periods of cortical synchronization and changes of spectral power qualitatively similar to those accompanying haloperidol administration. The drug slightly reduced the duration of arousal elicited by stimuli. Raclopride (1 and 3 mg/kg i.v.) induced weak EEG changes and little effect on arousal response to stimulation. There was an increase of slow wave activity which was particularly evident in the hippocampus. The data indicate that, although to a lesser degree, the D-1 receptor antagonist SCH 23390 induced EEG effects similar to those of haloperidol, whereas blockade of D-2 receptors by raclopride resulted in different patterns of EEG activity.
对能分别选择性作用于D-1或D-2多巴胺受体的抗精神病药物SCH 23390和雷氯必利，研究了它们对家兔脑电图（EEG）活动的影响。用于比较的氟哌啶醇（静脉注射0.3和1 mg/kg）可诱导皮层EEG活动同步化。EEG频谱分析显示，皮层全频率范围（0.1 - 38.5 Hz）及所有频段的功率增加，而海马中慢波和快波θ活动（3.7 - 7.2和7.2 - 12.2 Hz）略有下降。动物表现出镇静，对体感刺激的觉醒反应明显受到抑制。SCH 23390（静脉注射0.03和0.3 mg/kg）诱导的皮层同步化周期和频谱功率变化在性质上与氟哌啶醇给药时相似。该药物略微缩短了刺激引起的觉醒持续时间。雷氯必利（静脉注射1和3 mg/kg）引起的EEG变化较弱，对刺激的觉醒反应影响较小。慢波活动增加，在海马中尤为明显。数据表明，尽管程度较轻，D-1受体拮抗剂SCH 23390诱导的EEG效应与氟哌啶醇相似，而雷氯必利阻断D-2受体则导致不同的EEG活动模式。
