Eikelboom R H, Cooper R L, Barry C J
Lions Eye Institute, Nedlands, Western Australia.
Aust N Z J Ophthalmol. 1993 Nov;21(4):219-26. doi: 10.1111/j.1442-9071.1993.tb00960.x.
The red-free negatives of 53 right eyes (30 normal eyes and 23 glaucomatous eyes) and 51 left eyes (32 normal eyes and 19 glaucomatous eyes) were analysed using two different image densitometry techniques. The first technique measured the density from rectangular sample areas, while the second measured density from sector-shaped sample areas which more closely follow the course of the nerve fibres in the retina. Indices which measured the deviation of the data from a clinically determined normal 'gold standard' were calculated, and were used to determine the optimum sensitivity and specificity in separating normal from glaucomatous eyes. There is a significant difference between the data from the normal and glaucomatous groups of eyes, when measured from the sector sample areas. The relative efficacy of this technique is also shown by the improved values of sensitivity (from 42%-70% to 70%-91%), although specificity remained fairly constant (from 66%-83% to 62%-88%).
使用两种不同的图像密度测定技术，对53只右眼（30只正常眼和23只青光眼眼）和51只左眼（32只正常眼和19只青光眼眼）的无赤底片进行了分析。第一种技术从矩形样本区域测量密度，而第二种技术从扇形样本区域测量密度，扇形样本区域更紧密地遵循视网膜中神经纤维的走向。计算了测量数据与临床确定的正常“金标准”偏差的指标，并用于确定区分正常眼和青光眼眼的最佳敏感性和特异性。从扇形样本区域测量时，正常眼组和青光眼眼组的数据存在显著差异。该技术的相对有效性还体现在敏感性值的提高（从42%-70%提高到70%-91%），尽管特异性保持相当稳定（从66%-83%到62%-88%）。
