Yamazaki Y, Miyazawa T, Yamada H
Department of Ophthalmology, Nihon University, Tokyo, Japan.
Jpn J Ophthalmol. 1990;34(2):174-80.
A computerized digital image analysis system was developed to evaluate the retinal nerve fiber layer (RNFL) by red-free fundus photography. The image intensity of the RNFL was computed for 30 degrees between the disc and macula. Thirty early open-angle glaucoma patients and 30 normal age-matched subjects were examined. The coefficients of variation in the reproducibility of the measurements in normal subjects were 7.3 to 9.9% for the interphotographic studies, and 4.1 to 5.1% for the intraphotographic studies. Using this new image analysis system, the RNFL changes were detected easily and the glaucomatous eyes were distinguished from normal eyes with high sensitivity and specificity, 95% and 80%, respectively. This method will be useful for diagnosis of glaucoma at a very early stage.
开发了一种计算机化数字图像分析系统，通过无赤眼底摄影来评估视网膜神经纤维层（RNFL）。计算了视盘和黄斑之间30度范围内RNFL的图像强度。对30例早期开角型青光眼患者和30例年龄匹配的正常受试者进行了检查。正常受试者测量重复性的变异系数，摄影间研究为7.3%至9.9%，摄影内研究为4.1%至5.1%。使用这种新的图像分析系统，能够轻松检测到RNFL的变化，并且以高灵敏度和特异性（分别为95%和80%）区分青光眼眼和正常眼。该方法将有助于青光眼的极早期诊断。
