Shabo A L, Maxwell D S, Kreiger A E
Am J Ophthalmol. 1976 Feb;81(2):162-72. doi: 10.1016/0002-9394(76)90728-5.
The structural alterations induced in the monkey ciliary epithelium by intravascular injection of urea solutions were studied with the light and electron microscopes. Arterial injection of urea resulted in destruction of the nonpigmented epithelium and the consequent breakdown of the blood-aqueous barrier. The intravenous injection did not significantly affect the structural integrity of the ciliary epithelium. The intercellular zonulae occludens were not altered and the intercellular pathway from blood to posterior chamber remained closed to horseradish peroxidase. Intercellular uptake in large cytoplasmic vacuoles appeared to account for some late transport to the basal end of the nonpigmented epithelium. There was no comparable transport of peroxidase in vesicles or vacuoles through the nonpigmented epithelium in animals not subjected to intravenous urea treatment. Compared to the arterial route, intravenous administration of urea does not appear to pose a serious threat to the integrity of the ciliary epithelium.
通过光学显微镜和电子显微镜研究了血管内注射尿素溶液对猴睫状体上皮细胞结构的改变。动脉注射尿素导致非色素上皮细胞的破坏，进而导致血-房水屏障的破坏。静脉注射对睫状体上皮细胞的结构完整性没有显著影响。细胞间紧密连接未改变，从血液到后房的细胞间途径对辣根过氧化物酶仍保持封闭。在大的细胞质空泡中的细胞间摄取似乎是一些后期向非色素上皮细胞基端转运的原因。在未接受静脉尿素治疗的动物中，过氧化物酶没有通过非色素上皮细胞的囊泡或空泡进行类似的转运。与动脉途径相比，静脉注射尿素似乎对睫状体上皮细胞的完整性不构成严重威胁。
