Okisaka S, Kuwabara T, Rapoport S I
Invest Ophthalmol. 1976 Aug;15(8):617-25.
Hyperosmotic agents (2 M urea or 2 M DL-lactamide), perfused into the internal carotid artery of Rhesus monkeys, produced a marked decrease in intraocular pressure and an increase in aqueous humor protein. Fenestrae of the ciliary capillaries were broken immediately following the perfusion and the nonpigmented epithelium was separated from the pigmented epithelium. The pigmented epithelium especially of the pars plana then became degenerative. As intraocular pressure began to rise slowly, three to seven days after perfusion, the nonpigmented epithelium recovered to an almost normal structure, but the pigmented epithelium did not regenerate. The surviving cells in the pars plicata formed the original apico-apical junctions. The number of vacuoles in the endothelium of Schlemm's canal decreased while the intraocular pressure was low and increased gradually with the recovery of the intraocular pressure.
向恒河猴的颈内动脉灌注高渗剂（2M尿素或2M DL - 乳酰胺），可使眼压显著降低，房水蛋白增加。灌注后睫状毛细血管的窗孔立即破裂，无色素上皮与色素上皮分离。然后，尤其是睫状体扁平部的色素上皮发生变性。灌注后三到七天，随着眼压开始缓慢升高，无色素上皮恢复到几乎正常的结构，但色素上皮没有再生。皱襞部存活的细胞形成了原来的顶端 - 顶端连接。当眼压较低时，小梁网内皮细胞中的空泡数量减少，随着眼压恢复，空泡数量逐渐增加。
