编码人多巴色素互变异构酶/酪氨酸酶相关蛋白-2的cDNA的分子克隆与功能分析
Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2.
作者信息
Yokoyama K, Suzuki H, Yasumoto K, Tomita Y, Shibahara S
机构信息
Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Miyagi, Japan.
出版信息
Biochim Biophys Acta. 1994 Apr 6;1217(3):317-21. doi: 10.1016/0167-4781(94)90292-5.
We have cloned the cDNAs encoding tyrosinase-related protein-2 (TRP-2) from a human melanoma cDNA library. Transient expression of the isolated cDNA in HeLa cells established that TRP-2 is DOPAchrome tautomerase. Human TRP-2/DOPAchrome tautomerase is composed of 519 amino acids with a molecular weight of 59,000 and has about 84% identity with the mouse counterpart.
我们从人黑色素瘤cDNA文库中克隆了编码酪氨酸酶相关蛋白2（TRP-2）的cDNA。将分离得到的cDNA在HeLa细胞中瞬时表达，证实TRP-2是多巴色素互变异构酶。人TRP-2/多巴色素互变异构酶由519个氨基酸组成，分子量为59,000，与小鼠的对应物具有约84%的同源性。
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