Glauser M P, Heumann D, Baumgartner J D, Cohen J
Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Clin Infect Dis. 1994 Feb;18 Suppl 2:S205-16. doi: 10.1093/clinids/18.supplement_2.s205.
Septic shock is mediated by complex interactions of cells, cytokines, and humoral pathways. Clinical therapeutic strategies aimed at inhibiting selected pathways have been efficacious in subsets of patients. Experimental studies focusing on the activities of single cytokines have contributed to the understanding of the complex pathophysiology of septic shock. More precise delineation of the roles of each mechanism contributing to pathogenesis will permit the identification of subsets of patients who might benefit from particular therapeutic strategies and will guide the development of additional approaches to prevention and treatment.
脓毒性休克是由细胞、细胞因子和体液途径的复杂相互作用介导的。旨在抑制特定途径的临床治疗策略在部分患者中已显示出疗效。专注于单一细胞因子活性的实验研究有助于理解脓毒性休克复杂的病理生理学。更精确地描述每种致病机制的作用将有助于识别可能从特定治疗策略中获益的患者亚组，并指导开发更多的预防和治疗方法。
