关于三价铬配合物与细胞还原剂诱导的DNA损伤的体外研究。
In vitro studies on the DNA impairments induced by Cr(III) complexes with cellular reductants.
作者信息
Gulanowski B, Cieślak-Golonka M, Szyba K, Urban J
机构信息
Department of Basic Medical Sciences, Medical Academy, Wrocław, Poland.
出版信息
Biometals. 1994 Apr;7(2):177-84. doi: 10.1007/BF00140489.
The influence of Cr(III) complexes with ascorbic acid, cysteine and glutathione on DNA has been studied spectrophotometrically and chromatographically. The toxic and genotoxic activities of these complexes were also investigated. It was found that these complexes bind to DNA weaker than hexaaqua Cr(III) complexes. It could be explained through the greater strength of the bi- and tridentate ligands coordinated to chromium in comparison to water molecules. The formation of DNA-DNA intermolecular bonds and DNA interstrand cross-linking has been also observed. These complexes were found to be non-toxic and non-genotoxic in the bacterial test.
采用分光光度法和色谱法研究了铬（III）与抗坏血酸、半胱氨酸和谷胱甘肽形成的配合物对DNA的影响。还研究了这些配合物的毒性和遗传毒性活性。结果发现，这些配合物与DNA的结合比六水合铬（III）配合物弱。这可以通过与水分子相比，与铬配位的双齿和三齿配体具有更强的强度来解释。还观察到了DNA-DNA分子间键的形成和DNA链间交联。在细菌试验中发现这些配合物无毒性和遗传毒性。
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