金属化合物的Rec测定及致突变性研究。

Rec assay and mutagenicity studies on metal compounds.

作者信息

Kanematsu N, Hara M, Kada T

出版信息

Mutat Res. 1980 Feb;77(2):109-16. doi: 10.1016/0165-1218(80)90127-5.

Abstract

We carried out rec assays on 127 metal compounds with Bacillus subtilis to check their DNA-damaging capacity and mutagenicity. Certain compounds of beryllium, cobalt, cesium, iridium, osmium, platinum, rhodium, antimony, tellurium, thallium and vanadium were newly found to be positive in addition to those of known positive metals such as arsenic, cadmium, chromium, mercury, molybdenum and selenium. Reverse mutation assays with Escherichia coli and Salmonella strains showed that compounds of rhodium (RhCl3), tellurium (Na2H4TeO6, Na2TeO3) and platinum (PtCl4, (NH4)2PtCl6) are potent mutagens.

摘要

我们用枯草芽孢杆菌对127种金属化合物进行了回复突变试验，以检测它们的DNA损伤能力和致突变性。除了已知的阳性金属如砷、镉、铬、汞、钼和硒的化合物外，新发现铍、钴、铯、铱、锇、铂、铑、锑、碲、铊和钒的某些化合物也呈阳性。用大肠杆菌和沙门氏菌菌株进行的回复突变试验表明，铑（RhCl3）、碲（Na2H4TeO6、Na2TeO3）和铂（PtCl4、(NH4)2PtCl6）的化合物是强效诱变剂。