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人类与亚人类灵长类胎盘特异性蛋白质的比较研究(作者译)

[Comparative studies on placenta specific proteins in man and subhuman primates (author's transl)].

作者信息

Bohn H, Sedlacek H

出版信息

Arch Gynakol. 1975 Dec 30;220(2):105-21. doi: 10.1007/BF00667116.

Abstract

It is shown that in placentae and partly also in sera from pregnant monkeys (chimpanzee, baboon, rhesus monkey and cynomolgus) proteins occur which are immunochemically related to the human placental specific antigens HPL (human placental locatogen), SP1 (pregnancy specific beta1-glycoprotein), PP5 (placental protein 5) and HSAP (heat stable alkaline phosphatase). The immunochemical and physico-chemical properties of these monkey proteins are compared with those of the corresponding human proteins using gel diffusion test, immuno-electrophoresis, gel filtration and polyacrylamide gel electrophoresis. These antigens also have been localized in the tissue of human and monkey (cynomolgus) placentae by the immunofluorescent technique.

摘要

结果表明,在妊娠猴(黑猩猩、狒狒、恒河猴和食蟹猴)的胎盘以及部分血清中,存在一些蛋白质,这些蛋白质在免疫化学上与人类胎盘特异性抗原HPL(人胎盘催乳素)、SP1(妊娠特异性β1-糖蛋白)、PP5(胎盘蛋白5)和HSAP(热稳定碱性磷酸酶)相关。利用凝胶扩散试验、免疫电泳、凝胶过滤和聚丙烯酰胺凝胶电泳,将这些猴蛋白的免疫化学和物理化学性质与相应人类蛋白的性质进行了比较。通过免疫荧光技术,这些抗原也已定位在人和猴(食蟹猴)胎盘组织中。

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