Martin A D, Daniel M Z, Drinkwater D T, Clarys J P
School of Human Kinetics, University of British Columbia, Vancouver, Canada.
Int J Obes Relat Metab Disord. 1994 Feb;18(2):79-83.
Lipid and water together typically make up more than 90% of the body's adipose tissue mass. Although some reports have shown that the fraction of lipid in adipose tissue is greater in obese people than in lean ones, the quantitative relationship between adipose lipid fraction and overall adiposity of the body has never been investigated. We dissected six male unembalmed cadavers and weighed all adipose tissue (range 9.7-25.7 kg), allowing the calculation of percentage adiposity as 100 x total adipose mass/body mass (range 17.8-43.9%). Adipose tissue volume was determined by hydrostatic weighing of all portions of the dissected adipose tissue. For the six cadavers, whole body adipose tissue density ranged from 0.925-0.970 g/ml. Based on a three-component model of adipose tissue (lipid, water and dry fat-free solids), an expression for lipid fraction, F, was derived. After assuming densities for adipose lipid (0.905 g/ml), water at 36 degrees C (0.997 g/ml) and the dry fat-free component (1.38 g/ml), the equation simplified to F = 6.256/D-5.912, where D is adipose tissue density (g/ml). Lipid fraction was then calculated for each of the six cadavers: the range (0.54-0.85) was in excellent agreement with published data. There was a significant correlation (r = 0.95, P < 0.005) between calculated lipid fraction and percentage adiposity. The regression equation predicting lipid fraction from percentage adiposity was y = 0.327 + 0.0124x. We conclude that the estimated fraction of lipid in human adipose tissue shows both a wide range and a strong positive linear relationship with overall body fatness.
脂质和水通常共同构成人体脂肪组织质量的90%以上。尽管一些报告表明，肥胖者脂肪组织中的脂质比例高于瘦人，但脂肪组织脂质比例与人体总体肥胖程度之间的定量关系从未被研究过。我们解剖了6具未防腐处理的男性尸体，并对所有脂肪组织进行称重（范围为9.7 - 25.7千克），从而能够计算出肥胖百分比，即100×总脂肪质量/体重（范围为17.8 - 43.9%）。通过对解剖后的脂肪组织各部分进行静水称重来确定脂肪组织体积。对于这6具尸体，全身脂肪组织密度范围为0.925 - 0.970克/毫升。基于脂肪组织的三成分模型（脂质、水和无脂干固体），推导出了脂质比例F的表达式。在假设脂肪组织脂质密度为0.905克/毫升、36摄氏度水的密度为0.997克/毫升以及无脂干成分密度为1.38克/毫升后，该方程简化为F = 6.256/D - 5.912，其中D为脂肪组织密度（克/毫升）。然后计算了6具尸体各自的脂质比例：范围（0.54 - 0.85）与已发表数据高度吻合。计算出的脂质比例与肥胖百分比之间存在显著相关性（r = 0.95，P < 0.005）。从肥胖百分比预测脂质比例的回归方程为y = 0.327 + 0.0124x。我们得出结论，人体脂肪组织中脂质比例的估计值既显示出广泛的范围，又与总体肥胖程度呈现出强烈的正线性关系。
