Schmitt J, Schmidt C, Alan C, Haller C, Perrier P
Service de Médecine H-Hôpital Central (CHRU), Nancy.
Bull Acad Natl Med. 1993 Oct;177(7):1153-62; discussion 1162-4.
The analysis of anamnestic, clinical and arteriographic parameters in 127 young patients with arterial disease of the lower limbs allowed a definite distinction between thromboangiitis obliterans (TAO) and early-onset atheroma, even if the etiopathogenic of TAO is still obscure. The HLA gene frequency has been determined in 54 patients (14 TAO, 40 early atheroma) and has been compared with local blood donors and with caucased subjects from the IXth Workshop. The results (higher frequency of HLA A28, AX, B53 and BX in the TAO group) have, however, a dubious significance. Furthermore, there were no differences between TAO and early atheroma in a comparative study of immunological parameters (anti-nuclear antibodies, circulating immune complexes, C3, C4 and CH50, cryoglobulin) in 72 patients (22 TAO, 50 early atheroma). So, neither a genetic predisposition nor a dysimmunity could be involved in the pathogenesis of TAO.
对127例下肢动脉疾病年轻患者的既往史、临床和动脉造影参数进行分析，即便血栓闭塞性脉管炎（TAO）的病因仍不明确，但仍能明确区分血栓闭塞性脉管炎与早发性动脉粥样硬化。已对54例患者（14例TAO，40例早发性动脉粥样硬化）的HLA基因频率进行了测定，并与当地献血者以及第九次研讨会的白种人受试者进行了比较。然而，结果（TAO组中HLA A28、AX、B53和BX的频率较高）的意义存疑。此外，在对72例患者（22例TAO，50例早发性动脉粥样硬化）的免疫参数（抗核抗体、循环免疫复合物、C3、C4和CH50、冷球蛋白）进行的比较研究中，TAO和早发性动脉粥样硬化之间没有差异。因此，遗传易感性和免疫功能紊乱均不可能参与TAO的发病机制。
