Dutta P, Karmali R, Pinto J T, Rivlin R S
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Cancer Lett. 1994 Jan 30;76(2-3):113-9. doi: 10.1016/0304-3835(94)90386-7.
This study investigated whether the growth of transplanted mammary tumors is altered in rats by treatment with the antimalarial drugs chloroquine (CQ) and quinacrine (QN). Female inbred F344 rats were divided into three experimental groups. Animals were injected i.p. with either CQ, QN or normal saline for 5 days a week throughout the entire experimental period (25 days). After 7 days of drug treatment each rat received subcutaneously one 2-mm2 aliquot of R3230AC mammary adenocarcinoma in the mid-thoracic region. Eighteen days after implantation, all rats were sacrificed and tumors were excised, weighed and measured. The results indicate that weights and volumes of tumors as well as tumor-to-body weight ratios were significantly higher in CQ and QN-treated animals than those in saline-treated animals. The final body weights of rats treated with QN were significantly lower than those treated with saline. The prostaglandin E2 content of tumors was significantly reduced by CQ treatment. Erythrocyte glutathione reductase activity coefficient and reduced glutathione concentrations remained unaffected by both treatments. These results suggest that CQ and QN have significant stimulatory effects on the growth of mammary adenocarcinoma in rats.
本研究调查了用抗疟药物氯喹（CQ）和喹吖因（QN）处理大鼠后，移植性乳腺肿瘤的生长是否会发生改变。将雌性近交F344大鼠分为三个实验组。在整个实验期（25天）内，每周5天给动物腹腔注射CQ、QN或生理盐水。药物处理7天后，每只大鼠在胸中部皮下注射一2平方毫米的R3230AC乳腺腺癌组织块。植入18天后，处死所有大鼠，切除肿瘤并称重和测量。结果表明，CQ和QN处理组动物的肿瘤重量、体积以及肿瘤与体重之比均显著高于生理盐水处理组。QN处理的大鼠最终体重显著低于生理盐水处理的大鼠。CQ处理显著降低了肿瘤中前列腺素E2的含量。两种处理对红细胞谷胱甘肽还原酶活性系数和还原型谷胱甘肽浓度均无影响。这些结果表明，CQ和QN对大鼠乳腺腺癌的生长具有显著的刺激作用。
