Zipper J A, Dabancens A O, Guerrero A C
Department of Physiology and Biophysics, Faculty of Medicine, University of Chile, Santiago, Chile.
Biol Res. 1995;28(3):227-30.
Both quinacrine and chloroquine had been used as antimalarial agents. Furthermore, antineoplastic and antiviral effects have been described for quinacrine, while chloroquine has been described to induce viral replication and promote tumor growth. To search for differences in the growing rate of transplanted tumors, chloroquine or quinacrine were administered orally to AJ mice from 30 days previous to the inoculation of TA3 transplantable tumor cells, treatment being continued up to the end of the experiment. A control group, transplanted with tumor cells received tap drinking water. Marked differences between the three groups were found. Quinacrine had antitumoral effect, while chloroquine promoted a faster tumoral growth than controls. (p < 0.01). Results suggest caution in the use of chloroquine, because it might have a similar promoting effect on human neoplasia.
奎纳克林和氯喹都曾被用作抗疟药物。此外，有报道称奎纳克林具有抗肿瘤和抗病毒作用，而氯喹则被描述为可诱导病毒复制并促进肿瘤生长。为了寻找移植肿瘤生长速率的差异，在接种TA3可移植肿瘤细胞前30天开始，对AJ小鼠口服氯喹或奎纳克林，并持续给药至实验结束。一个移植了肿瘤细胞的对照组则饮用自来水。结果发现三组之间存在显著差异。奎纳克林具有抗肿瘤作用，而氯喹促进肿瘤生长的速度比对照组更快（p < 0.01）。结果提示在使用氯喹时应谨慎，因为它可能对人类肿瘤有类似的促进作用。
