Achiwa I, Shiozawa T, Nukaya H, Terao Y
Graduate School of Nutritional & Environmental Sciences, University of Shizuoka, Japan.
Chem Pharm Bull (Tokyo). 1994 Feb;42(2):408-9. doi: 10.1248/cpb.42.408.
A new mutagen, 2-amino-1,7,9-trimethylimidazo[4,5-g]quinoxaline (1), isolated from beef extract, was synthesized from 3-fluoro-2-methylaniline via an intermediate, 2,8-dimethyl-7-methylaminoquinoxaline (7a). Its 2-methylanalog (2) was also synthesized from the same intermediate. The synthetic 1 showed the same mutagenic activity as the isolated mutagen. However, 2 was non-mutagenic.
从牛肉提取物中分离出的一种新诱变剂2-氨基-1,7,9-三甲基咪唑并[4,5-g]喹喔啉（1），由3-氟-2-甲基苯胺经中间体2,8-二甲基-7-甲基氨基喹喔啉（7a）合成。其2-甲基类似物（2）也由同一中间体合成。合成的1显示出与分离出的诱变剂相同的诱变活性。然而，2无诱变活性。
