Safe S, Ellis B E, Hutzinger O
Can J Microbiol. 1976 Jan;22(1):104-6. doi: 10.1139/m76-014.
Incubation of 4'-chloro-4-biphenylol with a mushroom tyrosinase preparation gave the catechol, 4'-chloro-3,4-biphenyldiol as the sole in vitro metabolite. This compound was identical with the major rat urinary metabolite of 4'-chloro-4-biphenylol and thus confirms the structure assigned to the metabolite. This result also demonstrates a possible degradation pathway of hydroxylated chlorobiphenyls which are themselves the major metabolic degradation products of polychlorinated biphenyls.
将4'-氯-4-联苯酚与蘑菇酪氨酸酶制剂一起温育，得到儿茶酚4'-氯-3,4-联苯二酚作为唯一的体外代谢物。该化合物与4'-氯-4-联苯酚的主要大鼠尿液代谢物相同，从而证实了赋予该代谢物的结构。该结果还证明了羟基化氯联苯的一种可能的降解途径，而羟基化氯联苯本身是多氯联苯的主要代谢降解产物。
