Venter D P
Department of Pharmacology, Potchefstroom University for C.H.E., Republic of South Africa.
Eur J Pharmacol. 1994 Jan 14;251(2-3):209-20. doi: 10.1016/0014-2999(94)90402-2.
A theoretical model is presented to describe the functional interaction of an endogenous double agonist released by an indirectly acting agonist. The model takes into account the functional interaction of a released double (dualistic) agonist and describes both functional synergism and antagonism. It was shown that receptor density plays an important role in determining the profiles of concentration-effect curves and that it is necessary that the model should incorporate a parameter which describes receptor density. The model predicted that the shape of the concentration-effect curves may be sigmoid or bell-shaped. The theoretical predictions are comparable with experimental results.
提出了一个理论模型来描述由间接作用激动剂释放的内源性双重激动剂的功能相互作用。该模型考虑了释放的双重（二元）激动剂的功能相互作用，并描述了功能协同和拮抗作用。结果表明，受体密度在决定浓度-效应曲线的形态方面起着重要作用，并且该模型应纳入一个描述受体密度的参数。该模型预测浓度-效应曲线的形状可能是S形或钟形。理论预测与实验结果相当。
