Venter D P, Oliver D W
Eur J Pharmacol. 1987 Mar 17;135(2):183-91. doi: 10.1016/0014-2999(87)90610-8.
A theoretical model is presented to describe the receptor interaction of a drug which possesses indirect as well as direct pharmacological action. Sets of theoretical log concentration-effect curves predicted by this model are presented. The model predicts that the shape of the log concentration-effect curves may be sigmoid (S-shaped), biphasic (bell-shaped) or composed of a combination of two sigmoid curves, joined together by a plateau. The theoretical predictions are comparable with the results obtained from an experimental study.
提出了一个理论模型来描述一种具有间接和直接药理作用的药物的受体相互作用。给出了由该模型预测的理论对数浓度-效应曲线集。该模型预测，对数浓度-效应曲线的形状可能是S形、双相（钟形）或由两条S形曲线组合而成，并由一个平台连接。理论预测与实验研究结果相当。
