Crouzy R
C R Acad Hebd Seances Acad Sci D. 1975 Nov 10;281(19):1417-20.
In the Rat, injection of vasoplegics such as papaverine, NaNO2, sodium nitroprusside or prostaglandin E 2 into the subfornical organ, the antero-inferior part of the 3rd ventricle or the lateral ventricle blocks the dipsogenic action of angiotensin II (A II) injected through the same cannula practically completely without diminishing that of carbachol. This antagonism of A II by substances known to relax vascular smooth muscle supports our hypothesis that the mechanism of action of this dipsogenic substance, in contrast to that of carbachol, involves mechanoreceptors situated in special cavernous structures.
在大鼠中，向穹窿下器、第三脑室前下部或侧脑室内注射罂粟碱、亚硝酸钠、硝普钠或前列腺素E2等血管舒张剂，可几乎完全阻断通过同一套管注射的血管紧张素II（A II）的致渴作用，而不减弱卡巴胆碱的致渴作用。已知能舒张血管平滑肌的物质对A II的这种拮抗作用支持了我们的假设，即与卡巴胆碱不同，这种致渴物质的作用机制涉及位于特殊海绵状结构中的机械感受器。
