Lammers K M, Jansen J, Bijlsma P B, Ceska M, Tytgat G N, Laboisse C L, van Deventer S J
Center for Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Amsterdam, The Netherlands.
Gut. 1994 Mar;35(3):338-42. doi: 10.1136/gut.35.3.338.
Interleukin 8 is a neutrophil chemotactic and stimulating cytokine induced by various inflammatory stimuli, including tumour necrosis factor, interleukin 1, and endotoxin. The ability of HT 29/19A enterocytes to synthesise interleukin 8 was studied. The results show that interleukin 1 is an important stimulus for interleukin 8 synthesis and secretion by HT 29/19A cells, being more potent than tumour necrosis factor. The tumour necrosis factor and interleukin 1 induced interleukin 8 secretion by HT 29/19A cells was seen to be polarised according to the direction of stimulation. These results support the concept that mucosal cells (enterocytes) may play an important part in initiating mucosal inflammation. Furthermore, it is proposed that HT 29/19A cells constitute a tool to study stimulus directed polarised cytokine secretion.
白细胞介素8是一种由多种炎症刺激物诱导产生的中性粒细胞趋化性和刺激性细胞因子，这些刺激物包括肿瘤坏死因子、白细胞介素1和内毒素。研究了HT 29/19A肠上皮细胞合成白细胞介素8的能力。结果表明，白细胞介素1是HT 29/19A细胞合成和分泌白细胞介素8的重要刺激物，其作用比肿瘤坏死因子更强。HT 29/19A细胞受肿瘤坏死因子和白细胞介素1诱导分泌白细胞介素8的情况，根据刺激方向呈现出极化现象。这些结果支持了黏膜细胞（肠上皮细胞）可能在引发黏膜炎症中起重要作用的观点。此外，有人提出HT 29/19A细胞构成了一种研究刺激导向性极化细胞因子分泌的工具。
