子痫前期中的人类白细胞抗原（HLA）抗原共享
HLA antigen sharing in preeclampsia.
作者信息
Schneider K, Knutson F, Tamsen L, Sjöberg O
机构信息
Department of Clinical Immunology, Uppsala University Hospital, Sweden.
出版信息
Gynecol Obstet Invest. 1994;37(2):87-90. doi: 10.1159/000292531.
The association between human leukocyte antigens (HLA) and the development of preeclampsia (PE) was studied in 48 women with PE and their partners. In 20 of the families, the HLA antigens of the child were also determined. In 8 of 15 cases (53%) of primigravidae with PE, the child shared at least 2 paternal antigens with the mother, whereas this was the case in only 1 of 26 (4%) children of healthy mothers (p < 0.001). In contrast to this, none of 6 children of multigravidae with PE shared 2 paternal antigens with the mother. An increased homozygosity at the HLA-B locus was also seen in the children of primigravidae with PE (40 vs. 4%, p = 0.01).
对48名患有先兆子痫（PE）的女性及其伴侣进行了人类白细胞抗原（HLA）与先兆子痫发病之间关联的研究。在其中20个家庭中，还测定了孩子的HLA抗原。在15例患有PE的初产妇中，有8例（53%）孩子与母亲至少共享2种父系抗原，而健康母亲的26个孩子中只有1例（4%）是这种情况（p<0.001）。与此相反，患有PE的经产妇的6个孩子中没有一个与母亲共享2种父系抗原。患有PE的初产妇的孩子在HLA - B位点的纯合性也有所增加（40%对4%，p = 0.01）。
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