[Changes in TXB2/6-keto-PGF1 alpha ratio and their relation to blood lipids of Type A behavioral patterns].

To study the pathophysiological relation between Type A behavioral pattern and coronary artery disease, we analyzed the Type A behavioral pattern, serum triglycerides (TG), cholesterol (TC), high density lipoprotein cholesterol (HDLc), and TXB2, 6-keto-PGF1 alpha in 60 patients with coronary artery disease and 60 age-sex-matched healthy subjects. All of them had normal blood pressure. The results showed Type A behavioral pattern was more prevalent than Type B behavioral pattern in coronary artery diseased patients and the reverse was true in the controlled subjects (P < 0.025); TG, TC and TXB2/6-keto-PGF1 alpha ratio increased significantly in Type A behavioral pattern compared with Type B behavioral patients, but HDLc/(TC+TG) and the level of HDLc decreased significantly in the Type A behavioral pattern than in the Type B behavioral pattern (P < 0.05). The TG, TC increased significantly and 6-keto-PGF1 alpha HDLc decreased significantly in the coronary artery diseased patients (P < 0.05). However, the ratio of TXB2/6-keto-PGF1 alpha was inversely related to HDLc/(TC+TG) among the coronary artery diseased patients. The results of this cross-sectional study suggest that coronary artery disease is associated with Type A behavioral pattern through the metabolism of lipids and prostaglandins in various ways.