Wang G Q, Zou Z Z, Yu D P
Department of Infectious Diseases, First Affiliated Hospital, Harbin Medical University.
Zhonghua Nei Ke Za Zhi. 1990 Mar;29(3):138-40, 188.
Plasma concentrations of Thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) were dynamically measured with radioimmunoassay in 30 patients of epidemic hemorrhagic fever (EHF). It was found that the levels plasma TXB2 significantly increased and 6-keto-PGF1 alpha decreased in EHF patients as compared with those in controls. The more severe the patient's condition, the higher the level of TXB2 and the lower the level of 6-keto-PGF1 alpha. The ratio of TXB2/6-keto-PGF1 alpha was parallel with the severity of the patient's condition. Plasma TXB and TXB2/6-keto-PGF1 alpha ratio increased significantly in the hemorrhagic and shock group, while 6-keto-PGF1 alpha decreased significantly in the shock group. The results showed that there is a distinct imbalance of TXA2-PGI2 mediated through the increase of TXA2 and decrease of PGI2 in EHF. The imbalance of TXA2-PGI2 participates in the pathogenesis and pathophysiology of hemorrhage, shock and renal dysfunction.
采用放射免疫分析法动态检测了30例流行性出血热（EHF）患者血浆血栓素B2（TXB2）和6-酮-前列腺素F1α（6-酮-PGF1α）的浓度。结果发现，与对照组相比，EHF患者血浆TXB2水平显著升高，6-酮-PGF1α水平降低。患者病情越严重，TXB2水平越高，6-酮-PGF1α水平越低。TXB2/6-酮-PGF1α比值与患者病情严重程度平行。出血休克组血浆TXB及TXB2/6-酮-PGF1α比值显著升高，休克组6-酮-PGF1α显著降低。结果表明，EHF存在明显的TXA2-PGI2失衡，表现为TXA2增多，PGI2减少。TXA2-PGI2失衡参与了出血、休克及肾功能不全的发病机制和病理生理过程。
