Vácha J, Znojil V, Pospísil M, Holá J, Pipalová I
Institute of Pathological Physiology, Medical Faculty, Masaryk University, Brno, Czech Republic.
Int J Immunopharmacol. 1994 Jan;16(1):51-60. doi: 10.1016/0192-0561(94)90118-x.
Mild microcytic anemia (without changes in mean corpuscular hemoglobin concentration, MCHC) was discovered 6-14 weeks after a single s.c. administration of 4 mg of particulate glucan to C57BL/10ScSnPh mice serologically positive for murine hepatitis (MHV). The anemia was associated with granulocytosis, decreased body weight and spleen hypertrophy. The overall intensity of erythropoiesis was measured by 59Fe-incorporation into the heme of erythropoietic organs. The localization of erythropoiesis became markedly redistributed--heme production was suppressed in the bone marrow while a several-fold increase was recorded for the spleen. A new steady state was also discovered in ferrokinetics: an iron pool localized away from the blood, erythropoietic organs and the liver was significantly elevated, and hypoferremia was detected. Anemia and wasting of mice were not observed in the same mouse strain free of MHV. A single administration of particulate glucan resulted in late impairment of red blood cell formation in the C57BL/10ScSnPh mouse strain infected with the mouse hepatitis virus. The anemia shares a number of features with those observed for the anemia of chronic diseases.
对血清学检测鼠肝炎（MHV）呈阳性的C57BL/10ScSnPh小鼠皮下单次注射4mg颗粒状葡聚糖后6 - 14周，发现轻度小细胞性贫血（平均红细胞血红蛋白浓度，MCHC无变化）。该贫血与粒细胞增多、体重减轻和脾脏肥大有关。通过将59Fe掺入造血器官的血红素中测量红细胞生成的总体强度。红细胞生成的定位明显重新分布——骨髓中的血红素生成受到抑制，而脾脏中的血红素生成增加了几倍。在铁动力学中也发现了一种新的稳态：远离血液、造血器官和肝脏的铁池显著升高，并检测到低铁血症。在没有MHV的同一小鼠品系中未观察到小鼠贫血和消瘦。对感染小鼠肝炎病毒的C57BL/10ScSnPh小鼠品系单次注射颗粒状葡聚糖会导致红细胞生成的晚期损害。该贫血与在慢性病贫血中观察到的贫血有许多共同特征。
