Faust A, Burkart V, Ulrich H, Weischer C H, Kolb H
Diabetes Research Institute, University of Düsseldorf, Germany.
Int J Immunopharmacol. 1994 Jan;16(1):61-6. doi: 10.1016/0192-0561(94)90119-8.
In an animal model of type I diabetes, the non-obese diabetic (NOD) mouse, the influence of the antioxidant lipoic acid (LA) on the development of diabetes was investigated. Acceleration of diabetes development with cyclophosphamide (CY) resulted in 60% diabetic animals with severely infiltrated islets within 1-3 weeks. Daily administration of lipoic acid for 20 or 30 days around cyclophosphamide treatment suppressed the incidence of diabetes to 30% (P < 0.05) and 33%, respectively. Semiquantitative analysis of islet infiltration showed a reduction of severe intraislet infiltration and an increase in the percentage of islets with mild per-insular and periductular infiltrates (from 8.4 to 29.6 and 25.9%, respectively, P < 0.01) after lipoic acid treatment. These results show that the protective effect of lipoic acid on diabetes development correlates with partial suppression of islet inflammation. The anti-inflammatory action of lipoic acid may be due to its ability to scavenge oxygen radicals and to suppress nitric oxide production.
在I型糖尿病动物模型非肥胖型糖尿病（NOD）小鼠中，研究了抗氧化剂硫辛酸（LA）对糖尿病发展的影响。用环磷酰胺（CY）加速糖尿病发展导致1至3周内60%的糖尿病动物胰岛出现严重浸润。在环磷酰胺治疗前后每日给予硫辛酸20天或30天，可将糖尿病发病率分别降至30%（P<0.05）和33%。胰岛浸润的半定量分析显示，硫辛酸治疗后，胰岛内严重浸润减少，轻度胰岛周围和导管周围浸润的胰岛百分比增加（分别从8.4%增至29.6%和25.9%，P<0.01）。这些结果表明，硫辛酸对糖尿病发展的保护作用与胰岛炎症的部分抑制相关。硫辛酸的抗炎作用可能归因于其清除氧自由基和抑制一氧化氮产生的能力。
