Bonitati J
Clin Chem. 1976 Mar;22(3):341-5.
A gas-chromatographic analysis for the succinimide anticonvulsant drugs--ethosuximide, methsuximide, and phensuximide--in 1.0 ml of serum was modified to improve its reliability, speed, and precision. A separate procedure for 10-100 mul of serum was also developed. Neither method requires an initial preparation of derivatives. The working range of each method is about 10-100 mg/liter for the macro-method, 2-100 mg/liter for the micro-method. The methsuximide metabolite, N-desmethylmethsuximide, is included in both methods. Concentrations of N-desmethylmethsuximide in the blood of two patients with petit mal epilepsy are reported.
对1.0毫升血清中琥珀酰亚胺类抗惊厥药物（乙琥胺、甲琥胺和苯琥胺）的气相色谱分析方法进行了改进，以提高其可靠性、速度和精密度。还开发了一种用于10 - 100微升血清的单独方法。两种方法均无需预先制备衍生物。宏观方法的每个方法的工作范围约为10 - 100毫克/升，微观方法为2 - 100毫克/升。两种方法都包括甲琥胺的代谢物N - 去甲基甲琥胺。报告了两名失神性癫痫患者血液中N - 去甲基甲琥胺的浓度。
