烟曲霉产生的新型酰基辅酶A：胆固醇酰基转移酶抑制剂——吡喃并吡咯类化合物。II. 吡喃并吡咯类化合物A、B、C和D的结构解析
Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D.
作者信息
Kim Y K, Tomoda H, Nishida H, Sunazuka T, Obata R, Omura S
机构信息
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1994 Feb;47(2):154-62. doi: 10.7164/antibiotics.47.154.
The structures of pyripyropenes A, B, C and D, novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors, were determined mainly by spectroscopic studies including various NMR measurements. Pyripyropenes have a common structure which consists of pyridine, alpha-pyrone and sesquiterpene moieties. One of the three O-acetyl residues in the sesquiterpene moiety of pyripyropene A is replaced with an O-propionyl residue in pyripyropenes B, C and D.
新型酰基辅酶A：胆固醇酰基转移酶（ACAT）抑制剂吡啶并吡喃类A、B、C和D的结构主要通过包括各种核磁共振测量在内的光谱研究确定。吡啶并吡喃类具有由吡啶、α-吡喃酮和倍半萜部分组成的共同结构。吡啶并吡喃类A倍半萜部分的三个O-乙酰基残基之一在吡啶并吡喃类B、C和D中被O-丙酰基残基取代。
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