Tomoda H, Tabata N, Yang D J, Namatame I, Tanaka H, Omura S, Kaneko T
Research Center for Biological Function, Kitasato University, Kitasato Institute, Tokyo, Japan.
J Antibiot (Tokyo). 1996 Mar;49(3):292-8. doi: 10.7164/antibiotics.49.292.
Six new pyripyropenes, M to R, were isolated from the ethyl acetate extracts of the jar fermentation broth of Aspergillus fumigatus FO-1289-2501. Structural elucidation indicated that all the pyripyropenes have the same pyridino-alpha-pyrone sesquiterpene core as pyripyropenes A to L. Among them pyripyropene M showed the most potent inhibition against acyl-CoA : cholesterol acyltransferase activity with an IC50 value of 3.80 microM in rat liver microsomes, but pyripyropenes N to R showed moderate inhibitory activity (IC50 11.0 approximately 78.0 microM).
从烟曲霉FO - 1289 - 2501的广口瓶发酵液的乙酸乙酯提取物中分离出6种新的吡喃并吡咯烯类化合物，即M至R。结构解析表明，所有吡喃并吡咯烯类化合物都具有与吡喃并吡咯烯A至L相同的吡啶基-α-吡喃酮倍半萜核心。其中，吡喃并吡咯烯M对大鼠肝微粒体中的酰基辅酶A：胆固醇酰基转移酶活性表现出最强的抑制作用，IC50值为3.80微摩尔，而吡喃并吡咯烯N至R表现出中等抑制活性（IC50为11.0至78.0微摩尔）。
