Sobesky W E, Hull C E, Hagerman R J
Child Development Unit, The Children's Hospital, Denver, CO 80218-1088.
J Am Acad Child Adolesc Psychiatry. 1994 Feb;33(2):247-55. doi: 10.1097/00004583-199402000-00014.
The frequency of DSM III-R symptoms of schizotypal personality disorder as it relates to CGG amplification and to the cytogenetic expression of fragile X syndrome was explored.
Four groups of women were examined: 30 control mothers of children with developmental problems, 17 control women who grew up in fragile X families, 28 women cytogenetically negative but DNA positive for fragile X with a premutation, and 31 women who were DNA positive with an expanded mutation, most of whom were cytogenetically positive. All women were assessed using the Structured Interview for Schizotypy.
Eight of the nine women who received the DSM III-R schizotypal personality disorder diagnosis came from the two fragile X groups: four from the premutation group and four from the expanded mutation group. Twenty percent of fragile X carriers who received the gene from their mother, but none who received the gene from their father demonstrated schizotypal personality disorder.
Women who carry the premutation and women with the full mutation may both show schizotypal features, although less commonly than previously reported.
探讨分裂型人格障碍的DSM III-R症状频率与CGG扩增以及脆性X综合征细胞遗传学表达之间的关系。
对四组女性进行检查：30名发育问题儿童的对照母亲、17名在脆性X家庭中长大的对照女性、28名细胞遗传学检查阴性但DNA检测为脆性X前突变阳性的女性，以及31名DNA检测为扩增突变阳性的女性，其中大多数细胞遗传学检查为阳性。所有女性均使用分裂型人格结构化访谈进行评估。
在被诊断为DSM III-R分裂型人格障碍的9名女性中，有8名来自两个脆性X组：4名来自前突变组，4名来自扩增突变组。从母亲那里遗传了该基因的脆性X携带者中有20%表现出分裂型人格障碍，而从父亲那里遗传了该基因的携带者中无人表现出该障碍。
携带前突变的女性和具有完全突变的女性都可能表现出分裂型人格特征，尽管其发生率低于先前报道。
