Deguchi K, Yokota N, Koguchi M, Suzuki Y, Fukayama S, Ishihara R, Oda S, Tanaka S, Nakane Y, Fukumoto T
Section of Studies, Tokyo Clinical Research Center.
Jpn J Antibiot. 1994 Feb;47(2):161-9.
beta-Lactamase production and activities in sputa of patients with community-acquired lower respiratory tract infections (LRTI) were determined and following results were obtained: 1) Suspected causative organisms frequently isolated were H. influenzae and Streptococcus pneumoniae. Similar results were previously reported. 2) Various beta-lactamase producing indigenous bacteria were detected. In many cases these indigenous beta-lactamase producing strains were isolated even when suspected causative bacteria were not beta-lactamase producers. 3) beta-Lactamase activities were detected from 61.5% of the sputa tested. Remaining activities of antibiotics added to the sputa were highly correlated with detection of beta-lactamases produced by suspectedly causative and indigenous strains and with presence of beta-lactamase activities in the sputa. Sulbactam/cefoperazone was stable in sputa than other antibiotics tested. 4) We concluded that the beta-lactamase produced by indigenous strains can be one of the factors of indirect pathogenicity in the community-acquired LRTI.
测定了社区获得性下呼吸道感染（LRTI）患者痰液中的β-内酰胺酶产生情况及活性，结果如下：1）常见分离出的可疑致病微生物为流感嗜血杆菌和肺炎链球菌。此前曾报道过类似结果。2）检测到多种产生β-内酰胺酶的本土细菌。在许多情况下，即使可疑致病细菌不产生β-内酰胺酶，也能分离出这些产生β-内酰胺酶的本土菌株。3）在所检测的痰液中，61.5%检测到β-内酰胺酶活性。添加到痰液中的抗生素剩余活性与可疑致病菌株和本土菌株产生的β-内酰胺酶检测以及痰液中β-内酰胺酶活性的存在高度相关。舒巴坦/头孢哌酮在痰液中比其他测试抗生素更稳定。4）我们得出结论，本土菌株产生的β-内酰胺酶可能是社区获得性LRTI间接致病性的因素之一。
