Wittenberg J, Maturi R A, Williams L F, Teplick S K, Preblud S R, O'brien J J, Small D M
Invest Radiol. 1976 Jan-Feb;11(1):45-53.
One-hour infusion intravenous cholangiography with iodipamide was performed in 3 rhesus monkeys with intact enterohepatic circulations. A series of four different doses including standard (0.3 ml/kg) and "double dose" (0.6 ml/kg) levels were compared. The 0.6 ml/kg dose resulted in significantly higher biliary iodine excretion and concentration than the lower two doses. A 1.2 ml/kg dose probably increased biliary iodine concentration a small amount when compared to the 0.6 ml/kg dose but did not increase iodine excretion. Peak iodine excretion and concentration occurred, on the average, at one hour. The excretion of iodine in the bile demonstrated no inhibitory effect on the concomitant excretion of bile salts.
对3只肠肝循环完整的恒河猴进行了碘番酸一小时静脉胆管造影。比较了包括标准剂量（0.3毫升/千克）和“双倍剂量”（0.6毫升/千克）在内的四种不同剂量。0.6毫升/千克剂量导致的胆汁碘排泄和浓度显著高于较低的两种剂量。与0.6毫升/千克剂量相比，1.2毫升/千克剂量可能使胆汁碘浓度略有增加，但并未增加碘排泄。碘排泄和浓度峰值平均出现在一小时时。胆汁中碘的排泄对同时胆汁盐的排泄没有抑制作用。
