Evill C A, Benness G T
Invest Radiol. 1976;11(5):459-63.
Iodoxamic acid is a new hexaiodinated cholegraphic contrast agent. The methylglucamine salts of iodoxamate and iodipamide were administered to labrador dogs as an intravenous infusion. Bile salts were also infused. The biliary concentration and output of the two agents were compared. Bile flow rate, bile salt concentration and bile salt output with the two agents were also compared. The biliary output of iodoxamate (0.70-0.78 mumol/min/kg) was more than 50% higher than the iodipamide output (0.46 mumol/min/kg). Bile salt output and concentration with iodoxamate infusion were lower than with iodipamide infusion. The bile flow rate was higher with the new agent. The complementary effects of increased contrast output and decreased bile salt output with the new agent led to a significantly higher biliary iodine concentration compared with iodipamide. The results of this study support the suggestion that iodoxamate represents a significant advance in the cholegraphic contrast media field.
碘多啥酸是一种新型的六碘代胆道造影剂。将碘多啥酯和碘帕醇的葡甲胺盐以静脉输注的方式给予拉布拉多犬。同时也输注胆盐。比较了这两种药物的胆汁浓度和排出量。还比较了使用这两种药物时的胆汁流速、胆盐浓度和胆盐排出量。碘多啥酯的胆汁排出量（0.70 - 0.78微摩尔/分钟/千克）比碘帕醇的排出量（0.46微摩尔/分钟/千克）高出50%以上。输注碘多啥酯时的胆盐排出量和浓度低于输注碘帕醇时。使用新型药物时胆汁流速更高。与碘帕醇相比，新型药物增加造影剂排出量和减少胆盐排出量的互补作用导致胆汁碘浓度显著更高。这项研究的结果支持了碘多啥酯代表胆道造影剂领域重大进展这一观点。 （注：原文中“iodoxamic acid”疑有误，根据上下文推测可能是“iodoxamate”，译文按“碘多啥酯”翻译，具体可结合准确原文进一步确认。）
