Basenau D, Stehphani U, Fischer G
Zentrum Pathologie, Universität Göttingen.
Klin Padiatr. 1994 Jan-Feb;206(1):62-4. doi: 10.1055/s-2008-1046584.
The progression of alimentary fatty liver to liver cirrhosis is a very rare observation. During the year after surgical extirpation of a suprasellar craniopharyngioma in a seven years old boy developed severe obesity and again six years later at autopsy a complete liver cirrhosis with fatty liver was established. Injury of the ventromedial hypothalamic nuclei and resulting hyperphagia is the reason for the obesity following suprasellar tumours. The pathogenesis of liver cirrhosis following alimentary fatty liver is not completely evident up to now, such a progression is possible--as shown in this case--also in children and within a short period.
从营养性脂肪肝发展为肝硬化是一种非常罕见的情况。一名7岁男孩在接受鞍上颅咽管瘤手术切除后的一年内出现了严重肥胖，6年后尸检发现有脂肪肝伴完全性肝硬化。腹内侧下丘脑核损伤及由此导致的摄食过多是鞍上肿瘤后肥胖的原因。到目前为止，营养性脂肪肝后肝硬化的发病机制尚不完全清楚，如本病例所示，这种进展在儿童中也可能在短时间内发生。
