Müller H P, Lange D E, Müller R F
Department of Periodontology, University of Münster, Germany.
Oral Microbiol Immunol. 1993 Dec;8(6):344-8. doi: 10.1111/j.1399-302x.1993.tb00609.x.
Associations between recovery of Actinobacillus actinomycetemcomitans from samples of subgingival plaque, and samples of buccal mucosa, tongue and unstimulated saliva were studied in 107 subjects. Ten subjects had gingivitis, 18 localized juvenile periodontitis, 45 rapidly progressive periodontitis and 32 adult periodontitis. Two children suffered from prepubertal periodontitis. Heterogeneity tests for associations in different study populations yielded nonsignificant results. Mantel-Haenszel's common odds ratios were 52.9, 37.2 and 19.8 for respective associations between pooled subgingival samples, and cheek, saliva and tongue samples. Significant McNemar's chi-square of 5.88, 11.25 and 16.96 for respective associations pointed to secondary occurrence of A. actinomycetemcomitans in extracrevicular samples. Multiple linear regression yielded a significant influence of the number of deep periodontal pockets of 7 mm or more and a negative influence of the diagnosis "adult periodontitis" on the log-transformed number of colony-forming units of A. actinomycetemcomitans in samples from cheek mucosa in patients infected with the organism. Extracrevicular occurrence of A. actinomycetemcomitans seems to reflect total subgingival numbers of the organism. Especially sampling cheek mucosa appears to be a promising tool in the diagnosis of a periodontal infection with A. actinomycetemcomitans.
在107名受试者中研究了牙龈下菌斑样本、颊黏膜样本、舌样本和非刺激性唾液样本中伴放线放线杆菌的检出情况之间的关联。其中10名受试者患有牙龈炎，18名患有局限性青少年牙周炎，45名患有快速进展性牙周炎，32名患有成人牙周炎。两名儿童患有青春期前牙周炎。对不同研究人群中的关联进行的异质性检验结果不显著。对于合并的牙龈下样本与颊部、唾液和舌样本之间的关联，Mantel-Haenszel共同优势比分别为52.9、37.2和19.8。各关联的显著McNemar卡方值分别为5.88、11.25和16.96，表明伴放线放线杆菌在龈外样本中为继发性出现。多元线性回归显示，在感染该菌的患者中，7毫米及以上深度牙周袋的数量对颊黏膜样本中伴放线放线杆菌菌落形成单位的对数转换数有显著影响，而“成人牙周炎”诊断有负面影响。伴放线放线杆菌在龈外出现似乎反映了该菌在牙龈下的总数。尤其是采集颊黏膜样本似乎是诊断伴放线放线杆菌引起的牙周感染的一种有前景的工具。
