甲状腺素和丙基硫氧嘧啶对大鼠感染马来西亚后圆线虫的影响。
The influence of thyroxine and propyl thiouracil on Parastrongylus malaysiensis infection in rats.
作者信息
Kamis A B, Ahmad R A, Chang J S, Ambu S
机构信息
Jabatan Zoologi, Universiti Kebangsaan Malaysia, Bangi.
出版信息
Parasitol Res. 1994;80(1):87-8. doi: 10.1007/BF00932632.
Daily intramuscular injection with thyroxine (T4) at a dose of 2.5 micrograms/100 g body weight decreased the larvae and adult worm burden of Parastrongylus malaysiensis in the brain and pulmonary arteries of male Sprague-Dawley albino rats. In contrast, rats treated with propyl thiouracil (PTU), an antithyroid drug, at a dose of 3.75 mg/100 g body weight retained greater numbers of larvae and adult worms. The results may reflect the contrasting immunomodulatory effects of T4 and PTU that influence the susceptibility of the host.
每日以2.5微克/100克体重的剂量肌肉注射甲状腺素（T4），可降低雄性斯普拉格-道利白化大鼠大脑和肺动脉中马来副圆线虫幼虫和成虫的负荷。相比之下，以3.75毫克/100克体重的剂量用抗甲状腺药物丙硫氧嘧啶（PTU）治疗的大鼠，体内保留了更多数量的幼虫和成虫。这些结果可能反映了T4和PTU对宿主易感性产生影响的相反免疫调节作用。
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