Lockshin M D
Extramural Program, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, Maryland.
Rheum Dis Clin North Am. 1994 Feb;20(1):45-59.
The antiphospholipid syndrome is now well recognized and is separable from SLE, but better quantitation of both the clinical elements and the serologic definitions is still needed. It is likely for autoimmune but not for infection-induced aPL that the antigen is not phospholipid itself but a complex formed by phospholipid and beta 2 glycoprotein I. There are few treatment trials yet published. Those that are available suggest that antiplatelet therapy or anticoagulant therapy are more valuable than is immunosuppression.
抗磷脂综合征现已得到充分认识，且可与系统性红斑狼疮区分开来，但仍需要对临床症状和血清学定义进行更精确的量化。自身免疫性而非感染诱导的抗磷脂抗体中，抗原可能不是磷脂本身，而是由磷脂和β2糖蛋白I形成的复合物。目前发表的治疗试验较少。现有试验表明，抗血小板治疗或抗凝治疗比免疫抑制更有价值。
