Seeley R J, Galaverna O, Schulkin J, Epstein A N, Grill H J
Department of Psychology, University of Pennsylvania, Philadelphia 10104-6196.
Behav Brain Res. 1993 Dec 31;59(1-2):19-25. doi: 10.1016/0166-4328(93)90147-i.
Bilateral lesions of the central nucleus of the amygdala (CeAX) disrupt both need-free and need-induced NaCl intake. Quite surprisingly, in response to sodium depletion, the same rats who fail to augment their NaCl consumption dramatically increase the numbers of oral motor behaviors associated with ingestion that they display when NaCl is presented intraorally. The present study attempts to resolve these apparently contradictory results by measuring the intake of a NaCl solution delivered directly into the mouth. Controls enhanced their intraoral intake of 0.5 M NaCl in response to sodium depletion while CeAX rats did not. CeAX rats, however, showed discriminative intake responses to tastes. Like controls, CeAX rats promptly rejected 0.3 mM quinine infusions and ingested 1.0 M sucrose for prolonged periods. In addition, food deprivation enhanced the intraoral intake of a dilute sucrose solution in both CeAX and control rats. Thus, in the CeAX rat some tastes and some internal states modulate intake as they do in intact rats. These results are consistent with the hypothesis that central nucleus of the amygdala damage interferes with the consummatory phase of NaCl intake behaviors.
杏仁核中央核（CeAX）的双侧损伤会扰乱无需求和需求诱导的氯化钠摄入。相当令人惊讶的是，在钠缺乏的情况下，那些未能增加氯化钠摄入量的相同大鼠，当口腔内给予氯化钠时，它们表现出的与摄食相关的口腔运动行为数量会显著增加。本研究试图通过测量直接送入口腔的氯化钠溶液的摄入量来解决这些明显矛盾的结果。对照组在钠缺乏时增加了其口腔内0.5M氯化钠的摄入量，而CeAX大鼠则没有。然而，CeAX大鼠对味道表现出有区别的摄入反应。与对照组一样，CeAX大鼠迅速拒绝0.3mM奎宁输注，并长时间摄入1.0M蔗糖。此外，食物剥夺增强了CeAX大鼠和对照大鼠口腔内稀蔗糖溶液的摄入量。因此，在CeAX大鼠中，一些味道和一些内部状态与完整大鼠一样调节摄入量。这些结果与杏仁核中央核损伤干扰氯化钠摄入行为的 consummatory 阶段这一假设一致。
