Galaverna O G, Seeley R J, Berridge K C, Grill H J, Epstein A N, Schulkin J
Department of Biology, University of Pennsylvania, Philadelphia.
Behav Brain Res. 1993 Dec 31;59(1-2):11-7. doi: 10.1016/0166-4328(93)90146-h.
Bilateral damage to the central nucleus of the amygdala (CeAX) in the rat blunts need-induced NaCl intake and abolishes daily need-free NaCl intake when measured with a two-bottle test. Such a deficit could be the result of impaired taste function. To assess the taste function of the CeAX rat various taste stimuli were introduced directly into the oral cavity and taste-elicited oral motor responses were measured. Oral motor responses elicited by 0.62 M and 0.13 M sodium chloride, 0.3 M sucrose and 0.01 M citric acid, were similar in control and CeAX rats. Additionally CeAX and control rats acquired a taste aversion for fructose or maltose when either was paired with LiCl. Finally, in CeAX rats, like in control rats, the pattern of oral motor responses to 0.5 M NaCl was dependent on internal state; sodium depletion dramatically altered taste-elicited oral motor behavior. These results suggest that, in the rat, the deficits in NaCl intake behavior that follow CeAX do not appear to be a result of dramatic changes in gustatory function.
对大鼠杏仁核中央核（CeAX）的双侧损伤，在用双瓶测试测量时，会减弱需求诱导的氯化钠摄入，并消除每日无需求的氯化钠摄入。这种缺陷可能是味觉功能受损的结果。为了评估CeAX大鼠的味觉功能，将各种味觉刺激直接引入口腔，并测量味觉引发的口腔运动反应。0.62M和0.13M氯化钠、0.3M蔗糖和0.01M柠檬酸引发的口腔运动反应在对照大鼠和CeAX大鼠中相似。此外，当果糖或麦芽糖与氯化锂配对时，CeAX大鼠和对照大鼠都会产生对它们的味觉厌恶。最后，与对照大鼠一样，CeAX大鼠对0.5M氯化钠的口腔运动反应模式取决于内部状态；钠缺乏会显著改变味觉引发的口腔运动行为。这些结果表明，在大鼠中，CeAX后氯化钠摄入行为的缺陷似乎不是味觉功能发生显著变化的结果。
