Marchioni E, Maurelli M, Tartara A
Istituto Neurologico C. Mondino, Università di Pavia.
Boll Soc Ital Biol Sper. 1993 Jul-Aug;69(7-8):493-500.
The effects of catecholaminergic and opiatergic transmission inhibitors on CRF induced neurophysiological and autonomic patterns were tested. No interactions resulted between naloxone and CRF. Both DDC and MPT significantly reduced electrocortical and vegetative actions of CRF. Only the bradycardia was unmodified after premedications. Therefore our data confirmed the interactions between CRF and catecholaminergic pathways. The bradycardic effect seemed independent from the "stress-like" syndrome induced by CRF.
测试了儿茶酚胺能和阿片肽能传递抑制剂对促肾上腺皮质激素释放因子(CRF)诱导的神经生理和自主神经模式的影响。纳洛酮与CRF之间未产生相互作用。双脱氧可卡因(DDC)和甲基酪氨酸(MPT)均显著降低了CRF的电皮质和自主神经作用。预处理后仅心动过缓未改变。因此,我们的数据证实了CRF与儿茶酚胺能通路之间的相互作用。心动过缓效应似乎独立于CRF诱导的“应激样”综合征。