Herzog W R, Atar D, Gurbel P A, Vogel R A, Schlossberg M L, Serebruany V L
University of Maryland Medical Center, Department of Medicine, Baltimore.
Magnes Res. 1993 Dec;6(4):349-53.
The effect of magnesium sulphate infusion on ex vivo platelet aggregation in 11 female Yorkshire swine was observed using platelet-rich plasma and different agonists (ADP 5 mM; ADP 10 mM and collagen 1 mg/ml). Infusion of 1 g MgSO4 over 1 h produced a significant decrease in platelet aggregability. A dose-dependent effect of different ADP concentrations on platelet aggregation was noticed. Platelet inhibition was most consistent when using ADP 5 mM. We estimate this concentration of agonist as optimal in swine. The swine model is a good choice for investigation of in vivo platelet activation, especially with regard to cardiovascular research. We conclude that there is an inhibitory effect of supplemental magnesium on ex vivo platelet aggregation in swine with initial normomagnesaemia.
使用富含血小板血浆和不同激动剂（5 mM ADP；10 mM ADP和1 mg/ml胶原蛋白）观察了硫酸镁输注对11只雌性约克夏猪体外血小板聚集的影响。在1小时内输注1 g硫酸镁使血小板聚集性显著降低。注意到不同ADP浓度对血小板聚集有剂量依赖性作用。使用5 mM ADP时血小板抑制最为一致。我们估计该激动剂浓度在猪中是最佳的。猪模型是研究体内血小板活化的良好选择，特别是在心血管研究方面。我们得出结论，补充镁对初始血镁正常的猪体外血小板聚集有抑制作用。
