[中国吸烟与肺癌的Meta分析：十五项病例对照研究的合并分析]

[Meta-analysis of smoking and lung cancer in China: combined analysis of fifteen case-control studies].

作者信息

Zhao N

机构信息

Department of Epidemiology, Shanghai Medical College.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 1993 Dec;14(6):350-4.

PMID:8156580

Abstract

In the present paper, 15 case-control studies on the relation between smoking and lung cancer in China were analyzed by means of Meta-analysis method. The cumulative cases and controls were 5703 and 5669, respectively. Peto's model and Der Simonian and Nan Laird model were applied to process data. The pooled OR (smoking vs no smoking) was 3.01 (95% CI: 2.63-3.46) in males and 2.32 (95% CI: 2.02-2.66) in females. The PAR was 56.84% in males and 33.10% in females. There was significant dose-response relation between the amount of smoking, the years of smoking, the age at start of smoking and the OR for developing lung cancer. The pooled OR of squamous carcinoma was 4.79 (95% CI: 4.02-5.70), PAR was 65.44%. The pooled OR of adenocarcinoma was 1.02 (95% CI: 0.87-1.20), PAR was 0.99%.

摘要

在本文中，采用Meta分析方法对中国15项关于吸烟与肺癌关系的病例对照研究进行了分析。累积病例和对照分别为5703例和5669例。应用Peto模型以及Der Simonian和Nan Laird模型对数据进行处理。男性吸烟组与非吸烟组的合并比值比（OR）为3.01（95%可信区间：2.63 - 3.46），女性为2.32（95%可信区间：2.02 - 2.66）。男性人群归因危险度百分比（PAR）为56.84%，女性为33.10%。吸烟量、吸烟年限、开始吸烟年龄与患肺癌的OR之间存在显著的剂量反应关系。鳞状细胞癌的合并OR为4.79（95%可信区间：4.02 - 5.70），PAR为65.44%。腺癌的合并OR为1.02（95%可信区间：0.87 - 1.20），PAR为0.99%。