Yu L, Zhao N, Zhu Y J
Department of Internal Medicine, Peking Union Medical College Hospital.
Zhonghua Nei Ke Za Zhi. 1993 Oct;32(10):685-7.
Allergic granulomatous angiitis (AGA) is a rare disease, which varies in clinical manifestation. The clinical course includes three stages. In the first stage most of the patients show symptoms of respiratory disease, 82 per cent of the patients has asthma and 88 per cent chronic rhinitis. In the second stage there is blood eosinophilia and in the last stage involvement of multiple organs. The etiology is not yet clear. Since 1982 four cases of AGA have been encountered in PUMC Hospital, but they were all diagnosed after 1988. All were male and aged 36-54 years. Two of them had asthma history and three enlargement of liver and proteinuria, ECG showed heart block in two, all four had neuromuscular and cutaneous involvement and elevated blood eosinophil with absolute number ranging from 1254 to 8104/mm3. Biopsy from different sites showed panangiitis associated with eosinophil infiltration and/or granulomatosis formation. All were sensitive to prednisone therapy with or without CTX after treatment the absolute eosinophil count in the four patients was less than 1000/mm3 and the symptoms alleviated.
变应性肉芽肿性血管炎（AGA）是一种罕见疾病，临床表现多样。临床病程包括三个阶段。第一阶段，大多数患者出现呼吸道疾病症状，82%的患者有哮喘，88%的患者有慢性鼻炎。第二阶段出现血液嗜酸性粒细胞增多，最后阶段累及多个器官。病因尚不清楚。自1982年以来，北京协和医院共遇到4例AGA，但均在1988年后确诊。患者均为男性，年龄在36至54岁之间。其中2例有哮喘病史，3例有肝脏肿大和蛋白尿，心电图显示2例有心脏传导阻滞，4例均有神经肌肉和皮肤受累，血液嗜酸性粒细胞升高，绝对值在1254至8104/mm³之间。不同部位活检显示全血管炎伴嗜酸性粒细胞浸润和/或肉芽肿形成。所有患者对泼尼松治疗敏感，加用或不加用环磷酰胺，治疗后4例患者的嗜酸性粒细胞绝对计数均小于1000/mm³，症状缓解。
